Recent advances in human genetics at the Stanley Center have identified high-confidence risk genes for schizophrenia and bipolar disorder that are highly penetrant, promising real mechanistic insight into the pathophysiological mechanisms of psychiatric diseases.

A major focus of my lab is to study how loss of these genes effects brain function in mice, from the level of cellular signaling, through synaptic and circuity connectivity, up to behavior.

The end goal of these experiments are to identify convergent cellular processes, circuits, and brain regions across risk genes that can explain how the diseases manifest and offer promising therapeutic targets